003342 - Berkeley model Strain Details - The Jackson Laboratory
WEBThese mice display the major genetic, hematologic and histopathologic features observed in humans with sickle cell anemia and may be useful in studying sickle cell disease.
Sickle Cell Phenotypes in Townes & Berkeley Models | JAX
WEBPhenotype Information for JAX® Mice Strains Townes (013071) & Berkeley (003342) models. Townes model mice develop sickle cell disease in the presence of human knock-in alleles that replace mouse α-globin and β-globin. The Berkeley model also develops sickle cell disease due to a human hemoglobin transgene and …
Pathology of Berkeley sickle cell mice: similarities and differences ...
WEBFeb 2, 2006 · Because Berkeley sickle cell mice are used as an animal model for human sickle cell disease, we investigated the progression of the histopathology in these animals over 6 months and compared these findings to those published in …
Mouse models of sickle cell disease: Imperfect and yet
WEBJan 1, 2024 · The Berkeley and Townes SCD mice express only human globin chains and no mouse hemoglobin. With this genetic composition, these models present many phenotypic similarities, but also significant discrepancies that should be considered when interpreting preclinical studies results.
Characterization of a mouse model of sickle cell trait: parallels to ...
WEBIn the Berkeley (Berk) model of SCD, transgenic mice are homozygous knockout of all murine α and β haemoglobin genes (Paszty, 1997). To replace these genes, sickle mice express a transgene (Tg β S : Hu-miniLCRα1 G γ A γδβ S ) allowing these mice to express exclusively human sickle haemoglobin in their circulating erythrocytes (SS mice).
Pathology of Berkeley sickle cell mice: similarities and ... - PubMed
WEBFeb 15, 2006 · Because Berkeley sickle cell mice are used as an animal model for human sickle cell disease, we investigated the progression of the histopathology in these animals over 6 months and compared these findings to those published in …
(PDF) Pathology of Berkeley sickle cell mice: Similarities and ...
WEBMar 1, 2006 · Because Berkeley sickle cell mice are used as an animal model for human sickle cell disease, we investigated the progression of the histopathology in these animals over 6 months and...
Berkeley Scientists Develop Mouse Model For Sickle Cell Research
WEBResearch by Drs. Chris Paszty and Edward Rubin of Berkeley Lab's Life Sciences Division has reported the creation of a new strain of mice that carries human hemoglobin genes with no counteracting mouse genes. This enables the mice to develop all clinical manifestations of the sickle cell disease.
Mouse Models of Erythropoiesis and Associated Diseases
WEBNewer SCD model mice (Table 1) express exclusively human globins and overcome the failure of earlier models to exhibit faithful sickle cell pathology. They include the Berkeley model, the Birmingham model, and the San Francisco model [33–36]. None of these models express murine α- and β-globin genes.
Peripheral nerve pathology in sickle cell disease mice - PubMed
WEBJun 27, 2019 · These data are the first to characterize Berkeley SCD mice as a naturally occurring model of peripheral neuropathy. Widespread myelin instability is observed in nerves from SCD mice. This pathology may be explained by increased permeability of the blood-nerve barrier and, thus, increased access to c ….
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