C57BL/6 - Wikipedia
WEBC57BL/6, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease.
000664 - B6 Strain Details - The Jackson Laboratory
WEBC57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.
C57BL/6 Mice | Charles River - Charles River Laboratories
WEBThe C57BL/6 mouse is a multipurpose model that can be used for research into physiology, immunology, safety and efficacy, oncology and genetics, as well as mouse model creation. B6 mice are often preferred to other inbred mice in certain research disciplines such as metabolic research.
There is no such thing as a C57BL/6 mouse! - The Jackson Laboratory
WEBC57BL/6 substrains are not the same! Once a new C57BL/6 substrain is established, spontaneous mutations will arise in both the original colony, and the new colony. A subset of those mutations will spread through the colony by genetic drift and become fixed (homozygous in all mice).
Substrains matter in phenotyping of C57BL/6 mice - PMC
WEBJan 14, 2021 · In this paper, we review recent reports of phenotypic and genetic differences among C57BL/6 substrains, focus our attention on the proper use of C57BL/6 and other inbred strains in the era of genome editing, and provide the life science research community wider knowledge about this subject.
WEBThe C57BL/6 inbred strain was developed starting in 1921 by Clarence Little at the Jackson Labs. At that time, a “black subline” (C57BL) and a “brown subline” (C57BR) were established and bred independently. The C57BL subline was further separated into two sublines designated “subline 6” and “subline 10.”
C57BL/6 - an overview | ScienceDirect Topics
WEBThe C57BL/6 mouse is the most commonly used mouse strain in academic institutions. This is likely due to the use of C57BL/6 blastocysts for targeted mutant or knockout mice. Other strains used with some frequency in genetically-engineered model production are FVB and strain 129.
A three-dimensional, population-based average of the C57BL/6 …
WEBJul 13, 2020 · We here introduce a population based DAPI template reconstructed from 12 C57BL/6 mouse brains. This template enables automated registration and segmentation of DAPI-stained mouse brain...
C57BL/6 Strain Detail MGI Mouse MGI:2159769 - The Jackson …
WEBSep 3, 2024 · View mouse strain C57BL/6 : mutations, QTL, phenotypes, diseases, and references.
Experiments done in Black-6 mice: what does it mean? | Lab …
WEBApr 22, 2019 · The C57BL/6J (B6J) mouse was the first strain to have its genomic sequence published, and this strain is considered a gold standard in many research areas.