Congenic - Wikipedia
WEBIn genetics, two organisms that differ in only one locus and a linked segment of chromosome are defined as congenic. [1] Similarly, organisms that are coisogenic differ in one locus only and not in the surrounding chromosome.
3.3 COISOGENICS, CONGENICS, AND OTHER SPECIALIZED STRAINS
WEBCoisogenic strains are named with a compound symbol consisting of two parts separated by a hyphen: the first part is the full or abbreviated symbol for the original inbred strain; the second part is the symbol for the mutation or variant allele.
Congenic - an overview | ScienceDirect Topics
WEBCongenic. In subject area: Biochemistry, Genetics and Molecular Biology. Congenic dissection is a strategy in which individual loci that contribute to a polygenic disease (such as lupus) can be segregated into a collection of unique substrains, each bearing an individual locus; From: Systemic Lupus Erythematosus, 2007.
Congenic Strain - an overview | ScienceDirect Topics
WEBA congenic strain is a model organism generated through a custom-breeding strategy such that a discrete allele or section of a chromosome is moved (introgressed) from one strain, called the ‘donor strain’, to another strain, called the ‘recipient strain’.
Glossary:Congenic Strain - The Jackson Laboratory
WEBSep 3, 2024 · An inbred strain of mouse that contains a small genetic region (ideally a single gene) from another strain, but which is otherwise identical to the original inbred strain. Congenic strains are derived by backcrossing to a parental inbred strain for at least ten generations while selecting for heterozygosity at a particular locus.
Congenic – Knowledge and References – Taylor & Francis
WEBCongenic refers to a mouse line that is almost identical to other inbred strains, except for the substitution of an alien allele at a single histocompatibility locus that allows for the introduction of a foreign allele. Congenic strains differ at a specific locus or chromosomal segment while maintaining identical background genes.
CONGENIC Definition & Meaning | Dictionary.com
WEBCongenic definition: (of inbred animal cells) genetically identical except for a single gene locus. See examples of CONGENIC used in a sentence.
Congenic mice: cutting tools for complex immune disorders
WEBMar 1, 2003 · In this review, we provide an overview of the genetic analysis of autoimmune diseases and of the crucial role of congenic and consomic mouse strains in such research.
Congenic Strain - an overview | ScienceDirect Topics
WEBCongenic and consomic strains are marker-assisted backcross breeding strategies to isolate a homologous chromosome (consomic) or chromosomal segment (congenic) from one inbred strain onto the genetic background of another.
Analyzing complex traits with congenic strains - PMC
WEBWe propose a method that is based on comparing phenotypes for sequential pairs of congenic strains, beginning with the strain with the shortest congenic segment and the host strain, and then in a stepwise fashion to strains with progressively longer, overlapping congenic segments.
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