Mouse models of epithelial ovarian cancer for preclinical studies
WEBMar 3, 2021 · The ID8 cell line is the most widely used in syngeneic EOC mouse models and is derived from C57BL/6 mouse ovarian surface epithelial cells transformed by subsequent serial passage in vitro (Roby et al., 2000). Similar to xenograft models, syngeneic models can be classified by the site of injection.
Genetically defined syngeneic mouse models of ovarian cancer as …
WEBIn contrast, syngeneic models, such as the commonly used ID8 murine model (11), together with genetically modified versions of these cells (12, 13), have been extensively used to investigate the roles of the immune system in HGSC progression and to study therapeutic responses.
The Tumor Immune Profile of Murine Ovarian Cancer Models: An …
WEBJun 9, 2022 · ID8-p53 −/− and ID8-C3 tumors were most highly infiltrated by T cells, whereas STOSE and MOE-PTEN/KRAS tumors were primarily infiltrated by tumor-associated macrophages and were unique in MHC class I and II expression. MOE-PTEN/KRAS tumors were capable of forming T-cell clusters.
A Syngeneic Mouse Model of Epithelial Ovarian Cancer Port …
WEBJan 1, 2019 · Based on the finding that women with EOC are at risk for metastasis at a trocar site after laparoscopy, we developed a syngeneic murine model of port-site metastasis of EOC. We leveraged the ID8 murine EOC cell …
Interferon-ε is a tumour suppressor and restricts ovarian cancer
WEBAug 16, 2023 · To demonstrate that endogenous IFNε has tumour-suppressive activity in vivo, we established the preclinical model of orthotopic, syngeneic HGSOC with the ovarian cancer cell line ID8.
ID8: A syngeneic mouse model for testing ovarian cancer
WEBNov 1, 2017 · ID8-Luc is a novel syngeneic mouse model developed to treat orthotopic ovarian cancer. Ovarian cancer remains a significant unmet medical need with a relative 5-year survival rate of 17% in patients diagnosed with highly advanced stage IV …
WEBOf the 10 clonal lines, ID8 exhibited the highest tumor load. ID8 cell line is a highly published and well characterized cell line and is frequently used as a syngeneic mouse model for ovarian cancer.
Syngeneic Murine Ovarian Cancer Model Reveals That Ascites …
WEBMar 9, 2015 · Our study demonstrates that ascites-derived tumor cells from mice injected intraperitoneally with murine ovarian cancer cells (ID8) express increased mem GRP78 levels compared with ID8 cells from normal culture.
Targeting autocrine amphiregulin robustly and reproducibly inhibits ...
WEBApr 30, 2021 · Next, we tested the ID8 model, which is the most widely used murine model of OvCa . In our experiments, ID8 cells were implanted in female mice, and 10 days later mice were treated with mAb...
Comparative analysis of syngeneic mouse models of high-grade …
WEBNov 13, 2023 · Syngeneic mouse models allow for the generation of tumours comprising the full repertoire of non-malignant cell types but have expanded in number, varying in the cell type of origin, method...
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