PPARs as Metabolic Regulators in the Liver: Lessons from Liver …
WEBMar 17, 2020 · PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and liver cancer.
Hepatic lipid homeostasis by peroxisome proliferator-activated receptor ...
WEBDec 1, 2018 · Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master role in the differentiation and proliferation of adipose tissues.
USP22 regulates lipidome accumulation by stabilizing PPARγ in
WEBApr 21, 2022 · To further clarify whether USP22 in HCC tissues was correlated with PPARγ, ACC and ACLY, we performed IHC staining using HCC tissue microarrays (TMAs). The results revealed that USP22 protein ...
PPARs and Nonalcoholic Fatty Liver Disease - PMC - National …
WEBLiver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem. 2003; 278 :34268–34276. [ PubMed ] [ Google Scholar ]
Liver PPARα is crucial for whole-body fatty acid homeostasis ... - PubMed
WEBObjective: Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed in tissues with high oxidative activity that plays a central role in metabolism. In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD).
PPARδ attenuates hepatic steatosis through autophagy-mediated fatty ...
WEBFeb 27, 2019 · Using genetic, pharmacological and metabolic approaches, we demonstrate that PPARδ reduces intrahepatic lipid content and stimulates β-oxidation in liver and hepatic cells by an...
Peroxisome Proliferator-Activated Receptor Gamma Agonist …
WEBJul 3, 2020 · The PPAR-γ agonist inhibits HSC activation in vivo and attenuates liver fibrosis through several fibrogenic pathways. Potent fibrogenic factors such as PDGF, CTGF, and TGF-β1 were downregulated by the PPAR-γ agonist. Targeting PPAR-γ activity may be a potential strategy to control liver fibrosis.
PPARγ signaling and metabolism: the good, the bad and the future
WEBMay 7, 2013 · PPARα, the first PPAR to be identified, is expressed predominantly in the liver, heart and brown adipose tissue (BAT), where it is a major activator of fatty acid oxidation pathways and is the...
Regulation of peroxisome proliferator-activated receptor-γ in liver …
WEBNov 1, 2006 · PPARγ was overexpressed by using an additional adenoviral vector (AdPPARγ). Bile duct ligation was utilized to induce stellate cell activation and liver fibrosis in vivo; phenotypic effects (collagen I, smooth muscle α-actin, hydroxyproline content, etc.) were measured.
Liver PPARα is crucial for whole-body fatty acid homeostasis and …
WEBHepatocyte-specific peroxisome proliferator-activated receptor α (PPARα) function is dependent on nutritional status. Wild-type (WT) and PPARα liver knockout (Pparαhep−/−) male 8-week-old mice were fed ad libitum, fasted for 24 h, or fasted for 24 h …
- Some results have been removed
Skip to content