Immunological signature of chronic spontaneous urticaria (Review)
WEBApr 8, 2022 · Chronic urticaria (CU) is a condition characterized by intensely pruritic, edematous, erythematous papules lasting for more than 6 weeks. Over half of the cases have concomitant swelling of deeper tissues, known as angioedema.
Decreased peripheral basophil counts in urticaria and mouse model …
WEBSep 29, 2022 · Although there is no suitable mouse model that reproduces the pathogenesis of urticaria, repeated application of OX has been reported to shift the immune response toward Th2 and induce migration of basophils to the lesion site . In this report, basophils were reported to infiltrate the skin even two days after a …
Key genes and immune infiltration in chronic spontaneous urticaria…
WEBNov 15, 2023 · They further observed that OSMR gene silencing can significantly inhibit the activity of JAK/STAT3 signal pathway, promote cell proliferation and migration, and further inhibit epithelial cell apoptosis in a chronic autoimmune urticaria mouse model.
Gut microbiota facilitate chronic spontaneous urticaria
WEBJan 2, 2024 · 14 Altmetric. Metrics. Abstract. Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids...
Mast cell silencing: A novel therapeutic approach for urticaria and ...
WEBAug 22, 2023 · In this review, we will (1) review the role of MCs in pathogenesis of CU, highlighting similarities with other MC disorders in disease mechanisms and response to treatment; (2) explore current therapeutic strategies, categorized by nonspecific immunosuppression, targeted inhibition of MC activation and mediators, and targeted modulation of MC ac...
Mathematical-based morphological classification of skin eruptions ...
WEBDec 4, 2023 · Seirin-Lee et al. develop a mathematical model to analyze the shapes of skin eruptions and link these morphological features to in vivo pathological dynamics of chronic urticaria.
Decreased peripheral basophil counts in urticaria and mouse model …
WEBSep 29, 2022 · Then, we used mouse model of contact hypersensitivity with a single application of oxazolone, which is known to stimulate basophil infiltration, and investigated basophil counts in the skin, peripheral blood, and bone marrow.
WEBCU can be classified into two types: non-immune contact urticaria (NICU) and immune contact urticaria (ICU), a rash and flare-up reaction caused by direct contact with a symptomatic chemical or...
Artemisinic acid attenuated symptoms of substance P-induced …
WEBDec 1, 2022 · 4Artemisinic acid decreased the symptoms of substance P-induced chronic urticaria in the mouse model and alleviated secretagogue-induced local cutaneous and systemic anaphylaxis through the Lyn-PLC-p38-NF-κB signaling pathway. Artemisinic acid inhibited mast cell degranulation and pro-inflammatory cytokine production in vitro.
WEBDec 21, 2023 · Chronic spontaneous urticaria (CSU) is an inflammatory skin disorder that manifests with itchy wheals, angioedema, or both for more than 6 weeks. Mast cells and basophils are the key pathogenic drivers of CSU; their activation results in histamine and cytokine release with subsequent dermal inflammation.
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