Young receptors make smart mice | Nature
WEBSep 2, 1999 · Fresh evidence for this theory comes from studies of transgenic mice that have been engineered to overexpress a subunit of the NMDA receptor called NR2B. These mice are not only smarter than...
Surface phenotypes of naive and memory B cells in mouse and …
WEBDec 22, 2021 · Weisel and colleagues provide a resource that phenotypically profiles naive and memory B cells and provides a comparative analysis of memory B cells found in humans versus mice.
Surface phenotypes of naïve and memory B cells in mouse and …
WEBMBC differ from their naïve counterparts in many ways, but functional and surface marker differences are poorly characterized. In addition, though mice are the prevalent model for human immunology, information is limited concerning the …
A neuroscientist’s guide to transgenic mice and other genetic tools
WEBTopics covered include types of traditional transgenic mouse models (knockout, knock-in, reporter lines), inducible systems (Cre-loxP, Tet-On, Tet-Off) and cell- and circuit-specific systems (TetTag, TRAP, DIO-DREADD).
Human PBMC-transferred murine MHC class I/II-deficient NOG mice …
WEBNov 20, 2017 · Administration of human PBMCs into newly developed murine MHC class I- and class II-deficient NOG (NOG-dKO; NOG- Iab, B2m-double-knockout) mice showed sufficient engraftment of human immune cells...
Clinical hematological and biochemical parameters in Swiss, …
WEBDec 18, 2020 · This study used 20 male and 20 female mice from each of the Swiss (heterogeneous), BALB/c and C57BL/6 (isogenic) and B6D2F1 (hybrid) lineages, totaling 160 individuals; with 60 days of life mice were 60 days old (age).
TRAP2 MICE: A TOOL FOR UNDERSTANDING BRAIN CIRCUITS …
WEBOne hallmark of brain circuits activation is the transient expression in particular cell types of immediate early genes (IEG) such as Arc or Fos. Based on this principle, Targeted Recombination in Active Populations (TRAP2) transgenic mice have been developed.
Standardized and reproducible measurement of decision-making in mice …
WEBMay 20, 2021 · Mice are increasingly being used to study the neural mechanisms of decision making, taking advantage of the genetic, imaging and physiological tools that are available for mouse brains. Yet, the lack of standardized behavioral assays is leading to inconsistent results between laboratories.
Fate mapping via CCR2-CreER mice reveals monocyte-to …
WEB26 Aug 2020. Vol 6, Issue 35. DOI: 10.1126/sciadv.abb2119. Abstract. Whether monocytes contribute to the brain microglial pool in development or after brain injury remains contentious. To address this issue, we generated CCR2-CreER mice to track monocyte derivatives in a tamoxifen-inducible manner.
010636 - NSG B2m Strain Details - The Jackson Laboratory
WEBFor more information on these RFID chips, including our FAQ, please visit our Mouse Identification page . These NOD scid Il2ry null B2m null triple mutant mice combine the features of the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency, and the MHC class I molecule (beta-2 microglobulin) deficiency and are ...
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