Molecular mechanism of vimentin nuclear localization associated …
WEBOct 13, 2023 · Upregulated P62 regulates the subcellular localization of vimentin by controlling the movement of SUMO1 and SUMO2/3. Nuclear vimentin acts as a transcription factor and promotes cell migration via the CDC42-cathepsin B- and D-vimentin pathways.
Impact of Vimentin on Regulation of Cell Signaling and Matrix ...
WEBMar 11, 2022 · Thus, vimentin influences the subcellular localization and activity of MT1-MMP, which through its interactions with the β1 and αvβ3 integrins, facilitates collective cell migration through collagen matrices (Galvez et al., 2002).
Molecular mechanism of vimentin nuclear localization ... - PubMed
WEBOct 13, 2023 · In the nucleus, vimentin acts as a transcription factor that regulates CDC42, cathepsin B, and cathepsin D to promote PDC invasion and migration. Furthermore, animal experiments and human colorectal cancer specimens have confirmed the nuclear translocation of vimentin.
Vimentin in cancer and its potential as a molecular target for …
WEBJun 3, 2011 · Subcellular distribution and export of vimentin to the cell surface. Vimentin, being a cytoskeletal structural protein, is expected to be restricted to the cytosolic portion of cells; however, vimentin has been shown to be …
Vimentin filaments interact with the actin cortex in mitosis …
WEBSep 13, 2019 · STED microscopy showed vimentin filaments next to the actin cortex both in Vero cells, where the colocalization mask unveils the intimate contact between endogenous vimentin and cortical actin ...
Vimentin: from a cytoskeletal protein to a critical modulator of …
WEBJul 5, 2023 · Vimentin is an intermediate filament protein that plays a role in cell processes, including cell migration, cell shape and plasticity, or organelle anchorage.
Bidirectional Interplay between Vimentin Intermediate Filaments …
WEBMay 28, 2015 · We revealed that intermediate filaments control the subcellular localization of arcs by restricting their flow to the perinuclear, vimentin-dense region. Consequently, depletion of vimentin leads to relatively modest but significant increase in the width of flat lamellum at the leading edge.
Novel functions of vimentin in cell adhesion, migration, and signaling
WEBJun 10, 2007 · The effects of extracellular vimentin can be either positive or negative, for example it can enhance axonal repair but also mediates SARS-CoV-2 infection. In this review, we categorize the functional implications of extracellular vimentin based on its localization outside the cell.
Novel functions of vimentin in cell adhesion, migration, and …
WEBJun 10, 2007 · Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important.
WEBlular Localization of the Vimentin Network. Distinct localization patterns of vimentin in control, arc-depleted (Tm4 siRNA), and dorsal-stress-fiber-depleted (palladin siRNA) cells, stained with vimentin antibody (green) and fluo-rescent phalloidin (red) to visualize vimentin and F-actin, respectively. Scale bar, 10 m.