The Colts are currently riding a four-game losing streak, which is the fourth-longest active streak in the league. If the Colts want to end that, they'll have to dominate the 49ers in these three areas on Monday night.

San Francisco 49ers team reporter Briana Jeannel addresses fans’ biggest questions ahead of Week 16 vs. the Indianapolis Colts.

There was a scenario where Rivers could have been the quarterback for the 49ers in 2022. After Trey Lance (ankle) and Jimmy Garoppolo (foot) went down for the season, the 49ers were left with Purdy, the last pick of the NFL Draft.

The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster is too strong for that. However, this is a team that is falling apart and they have a few glaring issues that can be exposed by the right team.

Kyle Shanahan says WR Ricky Pearsall could play vs. the Colts despite missing practice as San Francisco eyes a playoff-clinching win.

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 at Lucas Oil Stadium.

The Indianapolis Colts and San Francisco 49ers understand the stakes Monday night. Both teams find themselves in the throes of tight division races where one more loss could eliminate them.

Colts injury report as Ricky Pearsall misses a second straight practice while McCaffrey and Trent Williams return ahead of Week 16.

The Indianapolis Colts may look to acquire a former Pro Bowler to help solve their precarious quarterback situation in 2026.