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Cardinals, San Francisco 49ers and Week 3

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· 19h

49ers hold off Cardinals in furious final minutes

The Arizona Cardinals face the San Francisco 49ers in a game on the NFL Week 3 schedule on Sunday, Sept. 27, 2026.

USA TODAY Touchdown Wire on MSN · 8h

8 thoughts, takeaways from 49ers' thrilling Week 3 win over Cardinals

· 8h

The 49ers dial up a hook-and-ladder play to open scoring against the Cardinals

· 1d

How to Watch Cardinals vs. 49ers: TV Channel, Live Stream, Time

The Arizona Cardinals visit the San Francisco 49ers on Sunday, September 27, 2026 at 4:05 p.m. ET from Levi's Stadium, Santa Clara, CA.

· 12h

Brock Purdy throws 4 TDs as 49ers hold off Cardinals

· 21h

4 Reasons the Cardinals Will Upset the 49ers in Week 3 (and 2 Reasons They Won't)

NFL

Jimmy Garoppolo's best throws from 2-TD game vs. Rams | Week 8

Watch all of San Francisco 49ers quarterback Jimmy Garoppolo's best throws from his 2-touchdown game in the 49ers' Week 8 NFC West road win over their rival Los Angeles Rams in the 2022 NFL regular season.

Arizona Cardinals at San Francisco 49ers odds, picks and predictions

Sunday in Santa Clara, Calif. Kickoff from Levi's Stadium is at 4:05 p.m. ET (FOX). Let's analyze NFL odds around the Cardinals vs. 49ers odds and make our expert NFL picks and predictions for the best bets.