A new study has shown that giving aromatase inhibitors instead of tamoxifen to premenopausal women with estrogen receptor positive (hormone-sensitive) breast cancer significantly reduces the risk of ...

Mechanism of Action of Aromatase Inhibitors and Tamoxifen. In contrast, aromatase inhibitors markedly suppress plasma estrogen levels in postmenopausal women by inhibiting or inactivating aromatase, ...

Two-thirds of breast tumours are oestrogen-receptor positive and 60–70% of these tumours respond to interventions that reduce the effects of oestrogen. Until recently, tamoxifen was the drug of choice ...

Purpose. The clinical and economic benefits of aromatase inhibitor (AI) therapy in early-stage breast cancer are reviewed. Summary. AI therapy has become a standard of care for the treatment of most ...

Aromatase, an enzyme located in the endoplasmic reticulum of estrogen-producing cells, catalyzes the rate-limiting step in the conversion of androgens to estrogens in many tissues. The clinical ...

Premenopausal women with ER-positive breast cancer experienced a decreased rate of recurrence when given an aromatase inhibitor, compared with those given tamoxifen. However, more research is still ...

Aromatase inhibitors cause unwanted side effects. More and more women are choosing not to take them, but is this a good idea? The decision to walk away from taking aromatase inhibitors is a choice ...

As mortality in breast cancer patients has improved, morbidity of treatment has become increasingly important. Cognitive dysfunction has been considered as a morbid condition that may possibly result ...

For postmenopausal women with hormone-receptor–positive breast cancer, the most effective duration for adjuvant therapy with an aromatase inhibitor remains unclear. In this prospective, phase 3 trial, ...

Aromatase inhibitors, when used for up to three years in combination with growth hormone, may effectively and safely help very short adolescent boys grow taller, new research suggests. Aromatase ...

After years of research, we finally understand how GLP-1s impact T on day 1 versus years later.

Aromatase inhibitors are a class of hormonal agents that form part of the therapy for some types of breast cancer. These agents are available as pills and may be started after initial surgery or ...