A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created ...

In a recent study published in Frontiers in Immunology, researchers investigated the anticancer effects of drugs targeting human tumor-associated macrophages (TAMs) in vivo. In humanized murine models ...

Flow cytometry enables researchers to label proteins of interest using fluorophore-conjugated antibodies and other fluorochromes. Much like immunohistochemistry, which produces two- or ...

Scientists at UT Health San Antonio have engineered the world’s first humanized mouse model with a fully functioning human immune system, marking a breakthrough for biomedical research that could ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most protein-coding genes with humans, their regulatory ...

Researchers have created a functional 'humanized' liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic ...

Antibodies are a critical feature of the human adaptive immune response. New immunotherapies require the production of selective and non-autoimmunogenic antibodies. These engineered antibodies can ...

Scientists have developed a functional human hepatic tissue in a mouse host. The human hepatic tissue, in the mice, is composed of human hepatocytes and non-parenchymal cells (NPCs) including human ...

A new study published in Microbiology Spectrum reports the establishment of a liver-humanized NSG-PiZ mouse model that is fully permissive to hepatitis B virus (HBV) infection. In this model, HBV can ...

For the first time, scientists have bred mice with fully fledged human immune systems. The researchers say these human-like animals will enhance drug development. When faced with an infection, these ...