Interleukin-12 -- a messenger molecule of immune cells -- was long considered to trigger the development of psoriasis. Now, researchers have shown that interleukin-12 does not actually cause the skin ...
Interleukin-12 (IL-12) is a heterodimeric cytokine that orchestrates innate and adaptive immune responses against malignancies. By driving T helper 1 differentiation and stimulating natural killer and ...
Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into tissue, although safer than viral vectors, ...
Autoantibodies against interleukin-12 (anti–interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with ...
Purpose: To maintain interferon gamma (IFNγ) induction by recombinant human interleukin-12 (rhIL-12) and enhance its activity against melanoma and renal cell cancer, a regimen of twice-weekly ...
To the Editor: Mannon et al. (Nov. 11 issue) 1 describe the safety of anti–interleukin-12 antibody (anti–interleukin-12) for the treatment of active Crohn's disease. Among the 44 recipients of ...
An international collaboration of researchers, including Imperial College London and UCLA, has developed a collagen-binding interleukin 12 strategy that lets CAR-T cells treat prostate cancer in mice ...
Combining intratumoral electroporation of interleukin-12 (IL-12) DNA (tavokinogene telseplasmid, or TAVO) with the immune checkpoint inhibitor pembrolizumab (Keytruda) led to clinical responses in ...
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