Over the last decade, DNA sequencing has enabled the detection of vast numbers of somatic mutations in normal tissues 1,2,3,4,5,6. Many mutations have no effect on cell behaviour, but may generate ...

Researchers have created the first complete map showing how hundreds of mutations in a key cancer gene affect tumor growth. By testing every possible mutation in a critical hotspot, they found that ...

Ongoing genomic studies of cancer are cataloguing extensive numbers of somatic variants. For example, genome sequencing studies have identified numerous cancer mutations across a wide spectrum of ...

A team of researchers at Southern Medical University has developed an AI application to help identify genomic tradeoffs between different types of mutations that occurred as humans evolved. In their ...

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body’s typically efficient DNA repair machinery and potentially affecting our health ...

Investigating how proteins interact is key to understanding how cells work and communicate. In a new study published in Nature Communications, FMI researchers have provided key insights into how ...

It's a fundamental principle of science: Correlation does not equal causation. Every cancer cell has genetic mutations, but not all of those mutations necessarily drive the cancer. A Harvard Medical ...

Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...