• Establishing pharmacologically relevant exposure levels and engagement are two key steps in target validation. • There is a need for better biomarkers to objectively measure biological states and ...

A key step towards reducing the burden of central nervous system (CNS) disorders is the identification of disease-specific biomarkers that can help predict, monitor, and guide treatment development.

The nervous system is emerging as an important regulator of both healthy and malignant cellular niches throughout the body. Governing organ development, tissue homeostasis and regeneration throughout ...

The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists at the University of ...

Many people are familiar with oncogenes - genes long known to be involved in cancers in humans, such as the gene "Src." What's less widely understood is that oncogenes didn't evolve just to cause ...

Researchers at Karolinska Institutet have developed a method that shows how the nervous system and sensory organs are formed in an embryo. By labeling stem cells with a genetic 'barcode', they have ...

New research from the Layden Lab at Lehigh has demonstrated that the gene mechanisms at work during neurogenesis in the brain actually predate the evolutionary development of the central nervous ...

Vanderbilt researchers, including those from the Vanderbilt Brain Institute, have made significant strides in understanding how the enteric nervous system—sometimes called the "brain" of the gut—forms ...

A new Yale study reveals that major organ systems in the body aren’t just passive structures operating on directions from command central — aka the brain — but instead are active participants in ...