Figure 1: Domain architecture and cryo-EM structure of human Dicer. Figure 2: A pre-siRNA spans human Dicer between the cap and branch while a pre-miRNA binds the platform of the enzyme. The ...
miRNAs are single-stranded RNA of 19–24 nucleotides that are predicted to regulate up to 30% of protein-encoding genes. miRNA have been implicated in a vast array of cellular processes including cell ...
In yeast cells, shown here, the Dicer protein protects DNA (bright blue) by helping to resolve conflicts between transcription and replication. If left unchecked, these conflicts can disrupt both ...
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