Oxetanes are four-membered oxygen heterocycles that have emerged as versatile motifs in drug design owing to their high ring strain, three-dimensional shape and capacity to modulate key ...

Researchers have pioneered a new catalytic transformation that converts epoxides into fluorinated oxetanes, a coveted but difficult-to-make class of drug molecules that escaped synthetic preparation ...

Researchers from the National University of Singapore (NUS) have pioneered a new catalytic transformation that converts epoxides into fluorinated oxetanes, a coveted but difficult-to-make class of ...

This novel reaction mechanism of oxetane ring formation breaks the conventional understanding that oxetane ring formation in the taxol biosynthesis pathway is achieved through a rearrangement reaction ...

Traditional ways of constructing the oxetane ring cannot directly produce α,α-difluoro-oxetanes, owing to a lack of suitable fluorine-containing precursors or reagents, or both. Furthermore, ...

A scheme showing two complex organic molecules with multiple ring systems: the one on the left contains a four-sided ring with an oxygen in it, and the one on the left is identical except that the ...