As the approval date for Bristol Myers Squibb’s (BMS) schizophrenia drug KarXT (xanomeline-trospium) fast approaches, the schizophrenia field eagerly anticipates a potential breakthrough in a ...

Local tumor conversion of a prodrug to an active agent using clinically relevant radiotherapy may herald a new era in targeted and directed cancer chemotherapy. This may lead to the development of ...

A NEW generation of illicit street drugs are virtually undetectable to authorities and only start working once they’re digested and broken down. Called prodrugs, their particular molecular structure ...

Add Yahoo as a preferred source to see more of our stories on Google. Drug traffickers have found a way to trick enforcement agencies by using one of the most potent tools our bodies have: our ...

Cancer drugs that stimulate the body’s immune system to attack tumors are a promising way to treat many types of cancer. However, some of these drugs produce too much systemic inflammation when ...

A research team at National Taiwan University found that abnormal blood flow activates CB1 receptors in endothelial cells, promoting vascular inflammation and dysfunction. Soy-derived isoflavone ...

A new study shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like molecule. A new ...

The downside of prodrugs is potential for drug interactions and differences in metabolism due to genetic polymorphisms. The activity of prodrugs may be diminished or eliminated in the absence of ...

The permeation of drugs through the skin is compromised by the presence of polar functional groups such as thiols, alcohols, phenols, imides or amides. By transiently masking these polar functional ...

Formaldehyde has been previously shown to play a dominant role in promoting synergy between doxorubicin (Dox) and formaldehyde-releasing butyric acid (BA) prodrugs in killing cancer cells. In this ...