The Purdue University Institute for Cancer Research Transgenic and Genome Editing Facility (TGEF) is a state-of-the-art facility offering a wide range of services for the production and support of ...

A well-characterized in vivo model of a1AT mutant Z liver injury, the PiZ mouse, is useful to better understand the pathways involved in this disease. The results of the referenced study show an ...

We have also established a number of transgenic mouse lines expressing FGFR-4 and Il-1α and are evaluating there phenotype and potential utility as mouse models of cancer and BPH. Polnaszek N, ...

Skye Bioscience (SKYE) announced preliminary data from a diet-induced obesity model in mice. Skye’s CB1-inhibiting antibody, nimacimab, ...

For example, certain tumour cell lines may serve as cancer models, and transgenic mice that express human beta-amyloid protein may serve as animal models of Alzheimer’s disease. Having more ...

Breakthrough polymer-based therapy shows promise in reversing Huntington's disease symptoms by preventing toxic protein ...

What do I need to do to have a transgenic or knockout mouse made? You must have a current approved protocol ... and/or re-animate the samples into live animals. However, any animal model or ...

Specific inhibitors that could prevent the loss of nerve cells in different mouse models of Alzheimer's disease uncovered.

reducing theefficiency of generating transgenic mice. Integrated copy number is also typically less than a standard transgenic construct. Successful generation of BAC transgenics is highly dependent ...

The third quarter marked an important transition for Skye as a metabolic-focused company with the launch of our Phase 2 obesity clinical trial for nimacimab. We believe our truly ...

The first transgenic mouse used to study Alzheimer’s disease was created in 1995. Now, there are more than 200 models, and the key for any study using preclinical models is to narrow the options ...