A well-characterized in vivo model of a1AT mutant Z liver injury, the PiZ mouse, is useful to better understand the pathways involved in this disease. The results of the referenced study show an ...

The Purdue University Institute for Cancer Research Transgenic and Genome Editing Facility (TGEF) is a state-of-the-art facility offering a wide range of services for the production and support of ...

We have also established a number of transgenic mouse lines expressing FGFR-4 and Il-1α and are evaluating there phenotype and potential utility as mouse models of cancer and BPH. Polnaszek N, ...

reducing theefficiency of generating transgenic mice. Integrated copy number is also typically less than a standard transgenic construct. Successful generation of BAC transgenics is highly dependent ...

What do I need to do to have a transgenic or knockout mouse made? You must have a current approved protocol ... and/or re-animate the samples into live animals. However, any animal model or ...

You are more like a mouse than you might think! Today, scientists are creating models of human genetic disease using mice, flies, worms, and other animals. But what do these models reveal about us?

Skye Bioscience (SKYE) announced preliminary data from a diet-induced obesity model in mice. Skye’s CB1-inhibiting antibody, nimacimab, ...

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key ...

For example, certain tumour cell lines may serve as cancer models, and transgenic mice that express human beta-amyloid protein may serve as animal models of Alzheimer’s disease. Having more ...

Specific inhibitors that could prevent the loss of nerve cells in different mouse models of Alzheimer's disease uncovered.

Breakthrough polymer-based therapy shows promise in reversing Huntington's disease symptoms by preventing toxic protein ...