Scientists have gene-edited a cane toad egg to prevent a hatchling growing past the tadpole stage. The gene knockout technique could be scaled up and potentially used to manage the invasive species.

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

The most common gene editing technique, CRISPR-Cas9, only modifies DNA. That's helpful in most cases, but it means that you can't use it to tackle RNA-based diseases. Thankfully, that might not be ...

As mentioned, different types of genetic modification can be made, including: Gene knockout – the removal or inactivation of a target gene. Deletion mutation – the removal of one or more nucleotides ...

A knockout cell line for liver cancer is an off-switch for a specific gene that has been linked with liver cancer growth. Learn more about knockout cells and how they're used.

Over the years, the O’Malley lab and colleagues have been particularly interested in SRC-3 and its role in cancer. SRC-3 is not only highly expressed in all human cancers and plays a role in cancer ...

In-vitro plant gene editing techniques that are used conventionally and have a long safety record are excluded from EU laws restricting the use of genetically modified organisms (GMOs), Europe's ...

“Our study shows that in many different cell types, CRISPR gene-editing can confer a selective advantage to cells harboring mutations in genes associated with cancer, such as p53 and KRAS ...

As a result, the team led by Rosenthal and Crawford figured out how to perform a gene knockout in the squid species Doryteuthis pealeii using the CRISPR-Cas9 system for targeted gene disruption.

The team has achieved the first gene knockout NSF pod using the squid Doryteuthis pealeii. That particular squid is described as an "exceptionally important" research organism for biology over the ...