Gene therapy protects against motor neuron disease in rats
University of Wisconsin–Madison researchers targeting a group of hereditary neurodegenerative diseases have found success ...
New AI model improves prediction power for genomics related to disease
To understand the workings of DNA in relation to disease, scientists at Los Alamos National Laboratory have developed the first multimodal deep learning model of its kind, EPBDxDNABERT-2, capable of ...
The EMBO Journal1d
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the ...
eLife6d
Acute Activation of Genes Through Transcriptional Condensates Impact Non-target Genes in a Chromatin Domain
Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...