Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine …
WEBJul 30, 2020 · The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice.
JAK inhibition enhances checkpoint blockade ... - Science | AAAS
WEBWe report a phase I clinical trial of the JAK inhibitor ruxolitinib with anti–PD-1 antibody nivolumab in Hodgkin lymphoma patients relapsed or refractory following checkpoint inhibitor immunotherapy. The combination yielded a best overall response rate …
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine ... - PubMed
WEBSep 25, 2020 · The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice.
WEBAdaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy. The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Infection with the SARS-CoV-2 B.1.351 variant is lethal in aged BALB…
WEBMar 9, 2022 · In this study, we demonstrate that infection with the SARS-CoV-2 B.1.351 variant (TY8-612 strain) induces bodyweight loss and inflammatory cytokine/chemokine production in wild-type laboratory mice...
Substrains matter in phenotyping of C57BL/6 mice - PMC
WEBJan 14, 2021 · In this paper, we review recent reports of phenotypic and genetic differences among C57BL/6 substrains, focus our attention on the proper use of C57BL/6 and other inbred strains in the era of genome editing, and provide the life science research community wider knowledge about this subject.
BALB/c - an overview | ScienceDirect Topics
WEBBALB/c mice are inbred strain and now over 230 generations from their origin in New York in 1920. BALB/c mice are distributed globally and among the five most widely used inbred strains in biomedical research, particularly in immunology and infectious disease research.
The BALB/c Mouse: Genetics and Immunology | SpringerLink
WEBThese characteristics have made the BALB/c mouse a model for identifying genes that determine susceptibility to infectious and neoplastic diseases. In 1985 the laboratory BALB/c mouse became 72 years old. The current filial generations are somewhere around 350 generations [MURPHY].
The BALB/c Mouse Model for the Evaluation of Therapies to Treat ...
WEBMar 3, 2023 · With respect to therapeutic evaluation, the BALB/c mouse model is a robust model of infection, typically using females 6–8 weeks old (Table 1). A target dose of approximately 20–50 LD 50 equivalents achieves an acute, lethal infection.
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine …
WEBSep 9, 2020 · The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice.