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Indianapolis Colts vs San Francisco 49ers Game Highlights | 2025 NFL Season Week 16 The San Francisco 49ers will face the Indianapolis Colts on Monday, December 22, 2025, at 8:15 PM EST (5:15 PM PST / 9:15 AM PHT on Dec 23). The game is a "Monday Night Football" matchup at Lucas Oil Stadium in Indianapolis, Indiana. Simulation Video Game - is ...
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