Mechanism of Cyclosporin, Tacrolimus and Sirolimus #immunosuppressants #pharmacology
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Mechanism of Cyclosporin, Tacrolimus and Sirolimus #immunosuppressants #pharmacology
Ciclosporin, Tacrolimus and Sirolimus are used as immunosuppressants. They are inhibitors of lymphocyte signaling to inhibit interleukin-2 production and action. Ciclosporin and Tacrolimus are calineurin inhibitors by binding to cyclophilin and FK binding protein (FKBP) respectively. Sirolimus binds to FKBP-12 to generate an immunosuppressive ...
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