All articles in Genes (ISSN 2073-4425) Vol 15, Issue 3, are now freely available to access, read and download: https://brnw.ch/21wIPuq COVER STORY: Infantile epileptic spasms syndrome (IESS) is a devastating developmental epileptic encephalopathy (DEE) consisting of epileptic spasms, developmental regression/stagnation, and hypsarrhythmia on EEG. A myriad of aetiologies are associated with IESS; approximately 40% of cases are genetic. Over 28 copy number variants and 70 single-gene pathogenic va