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The Spicy MD. on Instagram: "HIV causes immunocompromise by progressively destroying CD4+ T cells, which are the “command center” of the immune system—so as CD4 drops, the body loses coordination of both cell-mediated immunity (T-cell defense) and humoral immunity (B-cell antibody response). Early on, a person may look normal, but the immune system is quietly weakening; later, they become prone to opportunistic infections (like TB, Pneumocystis pneumonia, candidiasis, cryptococcal meningitis) an
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Classify Rx on Instagram: "🎯 Fluconazole (Best CNS Penetration) 📍 Excellent CSF levels: Achieves 70-80% of serum concentration in CSF - hydrophilic properties allow superior BBB crossing compared to other azoles 📍 Primary use: First-line for cryptococcal meningitis (after amphotericin B induction), candida CNS infections, coccidioidal meningitis - oral bioavailability ~90% 🎯 Voriconazole (Good CNS Penetration) 📍 Moderate CSF levels: Achieves ~50% of serum concentration in CSF - lipophilic b
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In advanced HIV, a weakened immune system (low CD4 count) allows opportunistic infections (OIs) like TB, PCP pneumonia, CMV, cryptococcal meningitis, and candidiasis to thrive. These infections arise because the body can’t fight pathogens it would normally control. Antiretroviral therapy (ART) restores immune function, reducing viral load and increasing CD4 counts, preventing OIs. Prophylactic antibiotics (e.g., cotrimoxazole) further prevent infections in severely immunocompromised patients. #h
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